Highlighting Tacrolimus and Vitiligo

Treatment combining narrowband ultraviolet B–spectrum radiation and tacrolimus ointment produced better results than NB-UVB alone.

In vitiligo, narrowband ultraviolet B (NB-UVB) spectrum radiation induces repigmentation of the depigmented skin, but treatments require frequent trips to phototherapy units. Perhaps combinations of NB-UVB and topical therapy might hasten resolution or decrease the number of treatments or the total dose of NB-UVB needed for response. Topical tacrolimus ointment 0.1% has been used, alone or with sunlight exposure, to prevent progression of vitiligo and foster repigmentation.

Investigators completed a prospective, bilateral, paired comparison study in 80 adult patients with generalized vitiligo. The researchers assessed and photographed two or more vitiligo patches in symmetric locations on the face, trunk, or extremities, and the patients app…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)