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Several reports have suggested that aminolevulinic acid plus blue or intense pulsed light has photorejuvenating benefits beyond the treatment of actinic keratoses. In this split-face, double-blind, randomized, placebo-controlled study funded by the manufacturer, 48 women with photodamage received two treatments, 3 weeks apart, of methyl aminolevulinate (MAL) plus red light on one half of the face and placebo plus red light on the other. The MAL was incubated for 3 hours under occlusion before an 8-minute red-light irradiation. One month after the second treatment, a blinded investigator assessed improvement of photodamage using the 5-point Dover global photodamage scale. One point was considered improvement, and improvement of more than one…