Interferon-γ: Possible Growth Factor for Melanomas

A UVB-mediated IFN-γ response may help melanoma cells evade anti-tumor immune activity.

An inflammatory infiltrate composed of lymphocytes and macrophages is a common histologic feature of melanoma. This composition, and the knowledge that some melanomas regress spontaneously (presumably because of an aggressive immune response), have prompted researchers to evaluate manipulation of the immune system for therapeutic benefit in melanoma. Interferon-γ (IFN-γ), which is produced by cells in the inflammatory infiltrate, has been considered a potent mediator of the anti-tumor response in a number of other tumors.

These investigators examined the role of IFN-γ in UV-induced melanoma development in a mouse model. Increased presence and activation of melanocytes in neonatal mouse skin was observed following UVB, but not UVA, exposure. …

Reviewing Author

Craig A. Elmets, MD

Disclosures

Consultant / Advisory board Astellas Pharmaceuticals

EquityVaxin

Grant / Research support NIH; NIH/NCI; Veteran’s Administration; Ferndale Laboratories; Kyowa Hakko Kirin Pharma, Inc.

Editorial boards Cancer Prevention Research; Photodermatology, Photoimmunology, & Photomedicine; UpToDate; eMedicine; Journal of Dermatological Sciences; JAMA Dermatology

Leadership positions in professional societies American Academy of Dermatology (Vice Chair, Committee on Science and Research); Photomedicine Society (Board of Directors)