Nervous Pemphigoid

Patients with certain neurological and psychiatric disorders have an increased risk for developing bullous pemphigoid.

The autoantibodies associated with bullous pemphigoid (BP180 or BPAg1) often react with the intercellular part of the hemidesmosome. Patients with certain neurologic diseases have increased levels of these autoantibodies in serum. The authors of two recent studies identified a possible clinical link between bullous pemphigoid and neurologic disease.

Langan and colleagues conducted a case-control study using computerized medical records from a large, population-based, general practice database in the U.K. Of 3453 patients with neurologic disease, bullous pemphigoid was diagnosed in 868 patients. The researchers found significantly increased risk for pemphigoid in patients with stroke, dementia, Parkinson disease, epilepsy, and multiple sclero…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)