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Infantile hemangioma (IH) has been treated with propranolol since 2008 (see JW Dermatol Jun 20 2008). To study the efficacy and safety of this beta-blocker, investigators performed a multicenter, retrospective study of 71 patients (56 female; age range 1–45 months). Propranolol was started before age 6 months in 50 infants. Five babies had subglottic hemangioma causing significant airway obstruction, 63 patients had received no prior treatment, 4 had failed to benefit from corticosteroids, and 4 had failed surgical treatment. Patients with PHACES syndrome were excluded.
After cardiologic evaluation, patients received two daily doses of propranolol (2 mg/kg/day, divided twice daily, for a minimum of 12 weeks; mean, 20 weeks). Blood pressure, …