FCGR2A as a Susceptibility Locus for Kawasaki Disease

A genome-wide association study points to a susceptibility locus linking Kawasaki disease to an immune mediator.

Kawasaki disease is a vasculitic disorder occurring primarily in children and characterized by distinctive mucocutaneous findings and a risk for coronary artery damage. Previously undertaken genome-wide association studies (GWASs) were of relatively small size and were not performed in highly susceptible North Asian populations.

To address this, Khor and colleagues performed a case-control GWAS in 2173 cases and 9383 controls of European and Asian descent. They further analyzed the 62 single nucleotide polymorphisms that initially met statistical significance in other cohorts from Taiwan, Korea, Hong Kong, and Shanghai. They identified a polymorphism with the greatest genome-wide significance in the FCGR2A gene, which encodes the FcγRIIA pro…

Reviewing Author

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology

FCGR2A as a Susceptibility Locus for Kawasaki Disease

Topics

Reviewing Author