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In patients with systemic lupus erythematosus (SLE), a finding of neutrophils has been associated with bullous disease. However, six reports of patients with disease termed “non-bullous neutrophilic lupus erythematosus” have now been published. Where in the LE spectrum such patients should be classified is unknown.
These authors report four additional cases in women, all of whom had known SLE and developed urticarial papules and plaques. One patient also had subcutaneous nodules. All biopsy samples revealed neutrophils with leukocytoclasia affecting the interstitial dermis, and one showed a neutrophil-rich panniculitis. Vasculitis was not observed, but vacuolar alteration along the dermo-epidermal junction was seen. Direct immunofluorescence…