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The golden retrievers weren't pipetting at the laboratory bench but were contributing their 2-century breeding history, their mild-to-moderate ichthyosis, and their DNA to identify a new phospholipase as a cause of ichthyosis in man and dog. Researchers have defined many individual diseases among autosomal recessive congenital ichthyoses, but familial cases remained without a known cause. Hark — friendly golden retrievers gallop to the rescue! This breed often displays an autosomal recessive ichthyosis that does not begin as a collodion fetus but is diagnosed clinically during the first decade of life.
A genome-wide association study in 12 affected retrievers lead to iden…