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Eosinophilic pustular folliculitis of infancy (EPFI) is a pruritic dermatosis characterized by scalp pustules. EPFI is related to adult eosinophilic pustular folliculitis (EPF), also known as Ofuji disease, and immunosuppression-associated EPF, typically seen in HIV patients.
Spanish investigators reviewed 15 cases seen over a 16-year period (the largest documented series) along with 46 cases from the literature. Presenting age ranged from birth to 36 months (mean, 6 months; male:female ratio, 4:1). Lesions appeared by 6 months in 70% and before 14 months in 95%. Isolated or clustered papules, papulopustules, or vesicles with an erythematous base were seen on the scalp in all patients, and on other sites in 40 patients (65%); 84% of patients…