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Genetic and environmental factors contribute to the complex pathogenesis of psoriasis. To better understand the burden of psoriasis worldwide, these researchers conducted a systematic review of the published literature, with an eye to how variables such as geographic location, gender, and age affect incidence and prevalence, and how variations in study design and definition of cases and prevalence affect epidemiology of the disease. They limited their analysis to rates in the general population, including 46 studies examining prevalence and 7 evaluating incidence.
In the U.S., prevalence ranged from 2.2% to 3.15%; in the U.K., the range was 1.3% to 2.6%. Prevalence rates were higher in southern and northeastern Europe than in the U.K. Closer…