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Livedoid vasculopathy is a chronic, often painful eruption of recurrent, small ulcerations, usually affecting the lower legs. This condition has been linked to a variety of coagulopathies, but even in the absence of an identifiable genetic clotting abnormality, the disease is characterized by observation of thrombotic plugging of the small vessels in skin biopsy samples. Therapy is aimed at lowering thrombophilic potential in affected patients. Rivaroxaban is a newly approved oral anticoagulant used for the prevention of thromboembolism. It blocks factor Xa and causes an irreversible inhibition of thrombin formation and the development of thrombi. It has no effect on platelets.
These authors report their observation of three patients treated…