TINCRing with Skin Development

The long, noncoding RNA TINCR regulates epidermal differentiation.

Within the entire genome, only 10f transcribed RNA actually codes for protein. Few noncoding RNAs (those that do not encode protein) have been well studied.

Terminal differentiation-induced ncRNA (TINCR) is identified by Kretz and colleagues as a long, noncoding RNA (IncRNA) that is upregulated >150-fold in the course of epidermal differentiation. TINCR expression is low in squamous cell carcinoma. Using a 3-D model of skin epidermal differentiation, the researchers found that inhibiting TINCR function did not affect stratification, but it severely compromised expression of differentiation markers, such as loricrin, filaggrin, and keratins 1 and 10. Ultrastructural components such as keratohyalin granules and lamellar bodies were lost, and e…

Reviewing Author

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology