Antireflux Surgery Does Not Reduce Risk for Esophageal Adenocarcinoma

Results from a Swedish case-control cohort study demonstrated an association between gastroesophageal reflux disease (GERD) and esophageal adenocarcinoma (N Engl J Med 1999; 340:825-31). However, the effect of antireflux surgery on risk for esophageal adenocarcinoma in patients with GERD has not been examined. Researchers performed this population-based retrospective study in the same Swedish cohort to elucidate the relation between antireflux surgery for GERD and risk for esophageal adenocarcinoma.

Data from national hospital and cancer registries from 1965 through 1997 were used to identify 66,965 patients with GERD who did not undergo antireflux surgery and 11,077 GERD patients who did undergo surgery. After researchers excluded data for …