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Use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) has been linked with reduced risk for esophageal carcinoma. However, the data to support this association are from relatively small observational studies, and risk estimates are imprecise. This systematic review and meta-analysis is the first to include data from epidemiologic studies of aspirin or NSAID use and esophageal cancer.
The authors conducted an extensive review of electronic databases, manually reviewed the literature, and consulted with experts. Studies were included if they were designed to evaluate exposure to aspirin or NSAIDs, to report esophageal cancer outcomes (squamous cell or adenocarcinoma), and to report relative risks (RRs) or odds ratios (ORs); each stud…