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Recent evidence suggests that nocturnal symptoms of gastroesophageal reflux disease (GERD) have more detrimental effects on health-related quality of life than diurnal symptoms do. However, despite a relatively large database of information on GERD, there is a paucity of data on nocturnal symptoms. To determine the prevalence of nighttime heartburn among patients with GERD, the American Gastroenterological Association commissioned a national telephone survey of 1000 adults who reported heartburn or regurgitation within the past 7 days or who were currently taking heartburn medication.
Heartburn was reported to occur daily by 25% of respondents, 1 to 2 times per week by 43%, and 3 to 6 times per week by 20%; frequency could not be quantified …