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Surgery is the standard approach for treating adenocarcinoma in Barrett's esophagus patients, but the combination of endoscopic mucosal resection (EMR) and photodynamic therapy (PDT) is a less invasive alternative. In this retrospective review, Mayo Clinic researchers compared outcomes among 88 patients with early-stage esophageal adenocarcinoma; 24 of these patients underwent treatment with EMR/PDT, and 64 patients underwent standard surgical resection.
Patients had stage 1 cancer, as determined by endoscopic ultrasound or histopathologic staging after surgery. The surgery group experienced more procedure-related complications than did the EMR/PDT group (31 vs. 4; P<0.01). No procedure-related deaths occurred in the EMR/PDT group, but 1 pro…