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Unlike the standard practice in some other countries, most patients undergoing esophagogastroduodenoscopies (EGDs) in the U.S. receive moderate sedation to facilitate their comfort and acceptance of the procedure. However, sedation increases risks, prolongs recovery, and increases direct and indirect costs. Unsedated ultrathin EGD (using 5 mm-6 mm endoscopes) has been proposed as an alternative to standard endoscopy with sedation. However, data to support its use are from single-center studies. In this U.S. multicenter, randomized trial, researchers compared peroral unsedated ultrathin EGD (5.9 mm or 6.0 mm) and conventional EGD (8.6 mm or 9.8 mm) with sedation in 80 patients who were scheduled to undergo elective, outpatient EGD at communi…