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Eosinophilic esophagitis is a chronic inflammatory disease characterized by prominent eosinophilic infiltration (>24 eosinophils/high-power field) of the esophageal epithelium. The disease generally affects young men (age range, 20-40) who report solid-food impaction of the esophagus. Although the appearance on endoscopy may seem normal, the esophageal mucosa may be fragile ("crepe papery" in texture) and prone to tearing with aggressive dilation. In this prospective case series, researchers followed 30 patients (22 men) who met clinical and histologic criteria for eosinophilic esophagitis.
All patients remained in good health and in a stable nutritional state during the follow-up period (mean, 7.2 years). Dysphagia persisted in 29 patients;…