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An empirical trial of acid-suppressive therapy with a proton-pump inhibitor (PPI) has been adopted widely as a diagnostic test for gastroesophageal reflux disease (GERD)-related symptoms, but evidence is lacking to support its use for diagnosing and treating GERD-related laryngitis. Researchers in Australia evaluated objective measurements of laryngeal symptoms after a 12-week trial of omeprazole in 20 (of 70) consecutive screened patients who had dysphonia for at least 3 months, laryngoscopically proven laryngitis, and no other obvious cause for laryngeal injury. Fifty patients were excluded because of other possible causes for laryngeal injury.
Patients completed symptom questionnaires and underwent ambulatory pH monitoring, upper endoscop…