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Proton-pump inhibitors (PPIs) are remarkably effective for the treatment of gastroesophageal reflux disease (GERD), yet some patients fail to have an optimal response. A correlation between treatment-related reduction of intragastric acid exposure and healing of erosive esophagitis has been reported. In this prospective study, researchers assessed the efficacy of PPI therapy in normalizing intraesophageal and intragastric pH in 50 patients with GERD (without Barrett esophagus [BE]) who had become asymptomatic during once or twice daily therapy with one of the five available PPIs.
Most patients were taking omeprazole, lansoprazole, or rabeprazole (mean duration, 5 years). Dual-channel, 24-hour pH monitoring with simultaneous intraesophageal a…