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Male sex is recognized as a specific risk factor for Barrett esophagus (BE). In fact, 90% of patients who develop esophageal adenocarcinoma are white males in their fourth or fifth decade of life. In most BE series, the ratio of males to females has been ≥2:1, but the sex disparity has not been explained. These investigators evaluated the sex-related prevalence of BE and explored pathophysiologic differences that might account for any sex-associated prevalence disparity.
Researchers conducted a retrospective analysis of approximately 800 chart records from patients who were referred to the Thoracic and Foregut Surgery Department at the University of Southern California. All patients had undergone extensive esophageal testing. BE diagnoses we…