Loading...
Endogenous fluorescence can detect metabolic and structural changes in human tissue. Thus, autofluorescence imaging could improve detection of early-stage dysplastic and malignant lesions of the mucosa that are invisible during white-light endoscopy. Tissue fluorescence can be examined by point-spectroscopic sampling of the mucosa or by processing fluorescence information to generate an endoscopic image. In two studies, researchers evaluated fluorescence imaging for detection of early cancer in patients with Barrett esophagus (BE).
In a randomized crossover study, 50 patients with BE underwent standard endoscopy and light-induced fluorescence endoscopy (LIFE). Procedures were performed at a single center by two endoscopists who were blinded …