Loading...
The term “dyspepsia” encompasses many different symptoms, and the pathophysiology of dyspepsia might vary with the predominant symptom. The Rome II working group suggested that dyspepsia patients be separated into two categories for clinical trials — those with predominant pain and those with other symptoms of discomfort.
To evaluate the association between predominant symptom types and their underlying pathophysiology, investigators in Belgium studied 720 consecutive patients (mean age, 41) who completed dyspepsia questionnaires to identify their single most-predominant symptom. Patients’ demographic, clinical, and pathophysiologic features were compared. Pathophysiology profiles were based on results of Helicobacter pylori testing, gastric…