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Gastroesophageal reflux disease (GERD) irritates the larynx. In fact, 10% of otolaryngologist visits result in diagnoses of GERD-induced laryngeal injury, referred to as laryngopharyngeal reflux (LPR). The pathophysiology of LPR is poorly understood but might be related to microaspiration of gastric contents into the larynx. Medical therapy for the condition is only moderately successful, with many patients continuing to have persistent symptoms despite aggressive acid-suppressive therapy with proton-pump inhibitors (PPIs).
In this prospective study, researchers offered laparoscopic Nissen fundoplication to 25 patients with suspected LPR who had not responded to 4 months of high-dose PPI therapy. While taking PPIs, all patients had experienc…