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Causative factors have been identified in the development of laryngeal cancer: smoking in particular, but also alcohol consumption. The roles of other genetic, environmental, viral, and occupational aspects remain to be established. Because gastroesophageal reflux disease is prevalent in patients with laryngeal cancer, it has been proposed to have a causal role. A recent meta-analysis of studies on the effects of GERD on laryngeal cancer (Laryngoscope Mar 2005; 115:486) showed a significant associated risk (odds ratio, 2.37; 95% CI, 1.38–4.08), but the studies might have been subject to bias and confounding by inappropriate control data.
A matched case-control study based on chart review in a single tertiary care center was conducted to eval…