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Osteoporosis affects millions of adults, and hip fracture is the main manifestation of senile osteoporosis. Among many risk factors proposed to increase risk for hip fractures are conditions that cause low calcium absorption. Because gastric acid facilitates absorption of insoluble ingested calcium, drugs that inhibit gastric acidity might result in decreased absorption.
In this nested case-control observational study, researchers used a large U.K. database to compare 13,556 patients with incident hip fractures to135,386 age- and sex-matched controls. The investigators compared health conditions and use of medications, including proton-pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs). Risk for hip fracture was significantl…