Long-Term Outcomes in Overlap Syndrome of Primary Biliary Cirrhosis and Autoimmune Hepatitis

Varices, GI bleeding, ascites, and the composite outcome of liver transplant or death were all more common among patients with both PBC and probable AIH than among those with PBC alone.

Primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) have been identified in the same patients — a coexisting state known as overlap syndrome. Evidence shows that patients with PBC benefit from ursodiol therapy, whereas those with AIH receive immunosuppressive therapy; however, we know very little about the natural history, optimal treatment strategy, and long-term outcomes of PBC-AIH overlap syndrome.

A cohort of 137 PBC patients (mean age, 61; 87% women) from a previous Mayo Clinic study were evaluated for AIH using a revised scoring system for overlap syndrome that was proposed by the International Autoimmune Hepatitis Group (J Hepatol 1999; 31:929). Based on these criteria, probable overlap syndrome was diagnosed in 26 patients…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Long-Term Outcomes in Overlap Syndrome of Primary Biliary Cirrhosis and Autoimmune Hepatitis

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Reviewing Author