How Are GER and Metabolic Syndrome Related?

Univariate analysis shows that the prevalence of GER rises with increases in BMI, blood pressure, triglyceride levels, and fasting blood glucose levels.

Although a clear link exists between gastroesophageal reflux (GER) and obesity, the association between GER and other obesity-related complications, such as metabolic syndrome, has not been explored. Metabolic syndrome — which afflicts more than 50 million people in the U.S. — is characterized by abdominal obesity, atherogenic dyslipidemia, hypertension, diabetes, and prothrombotic and proinflammatory states.

In a retrospective analysis, Japanese researchers studied whether individual components of metabolic syndrome are associated with the prevalence of GER. They evaluated 5159 patients (3599 men) who underwent upper gastrointestinal endoscopy during health screening evaluations for 5 consecutive years as part of their health plan. All part…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors