Elevated Serum Aminotransferase Levels and Long-Term Survival

In a prospective, community-based study of asymptomatic adults, 10-year mortality rates were significantly higher for those who had elevated aminotransferase levels at baseline than for those who did not.

Few data are available, especially in the U.S., to indicate that elevated serum aminotransferase levels in asymptomatic adults are predictive of early mortality. To address this gap, researchers conducted a prospective study among all adults who were living in Olmstead County, Minnesota, in 1995 and had at least one healthcare visit (of any type) during that year.

Of the 54,586 study participants, 18,401 had their aspartate aminotransferase levels measured during 1995, and 6823 had their alanine aminotransferase levels measured that same year. Levels were categorized as abnormal if they were 1 to 2 times the upper limit of normal (ULN). Standardized mortality ratios (SMR) were calculated to determine the association between baseline aminotra…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose