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Gastric cancer is the second-leading cause of cancer death in the world. Intestinal-type gastric cancer has been associated with Helicobacter pylori infection and chronic gastritis. Diffuse-type gastric cancer, including linitis plastica, seems to have a distribution that is independent of the prevalence of H. pylori and might be more dependent on genetic factors. A germ-line mutation in the CDH1 gene has been identified in some pedigrees of diffuse-type gastric cancer in Japan. However, other pedigrees do not exhibit this mutation.
Investigators looked at two large genetic databases, one in Korea and one in Japan, that included information about patients with a variety of disorders, including gastric cancer, to identify single-nucleotide po…