Can Gene Expression Predict HCC Recurrence?

New study data demonstrate that gene-expression analysis might be able to identify HCC patients who are at higher risk for late tumor recurrence and who could benefit from closer surveillance or more-intense treatment.

Genomewide expression profiling has shown promise for predicting outcomes in hepatocellular carcinoma (HCC) patients. However, development of genome-based predictors has been hampered by the requisite use of frozen tissue samples. Now, investigators have tested whether a novel gene-expression profiling technique in formalin-fixed, paraffin-based tissue samples can predict survival in HCC patients.

Gene-expression profiling of more than 6000 human genes was performed in a training set of tissue samples from 106 Japanese patients with surgically resected HCC. Genes whose expression was associated with disease-specific survival and time to recurrence were selected by using Cox regression analysis. Model validation then was performed on samples …

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose