Sequential vs. Standard Triple Therapy for H. pylori Eradication

The eradication rate with sequential triple therapy was 84%, which is slightly higher than the rate previously reported for standard triple therapy.

Standard triple therapy for Helicobacter pylori eradication has a worldwide success rate of less than 80%, and this rate varies with the prevalence of antibiotic resistance and the specific H. pylori strain. Might the eradication rate be better if the therapy were administered sequentially rather than simultaneously? Recent data from Italy seem to support this approach (JW Gastroenterol Jun 15 2007), and now investigators in Spain have evaluated the efficacy of sequential treatment under clinical conditions.

This pilot study involved 139 patients who tested positive for H. pylori infection. All received twice-daily proton-pump inhibitor (PPI) therapy and amoxicillin (1 gm) for 5 days, followed by twice-daily treatment with a PPI, clarithromy…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose