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Dyspepsia is a complex of epigastric symptoms that have unclear, and likely complicated, heterogeneous etiologies. Attempts to associate symptoms with specific physiologic abnormalities have yielded variable results (JW Gastroenterol Mar 28 2006). Now, investigators have studied 218 Belgian patients with functional dyspepsia; characterized the temporal course of postprandial symptoms; and compared those symptoms with changes in gastric emptying, accommodation, and hypersensitivity.
Eligible patients had normal endoscopy results and no heartburn. Meal-related symptom aggravation was determined at baseline. No patients were taking nonsteroidal anti-inflammatory drugs, and only eight were infected with Helicobacter pylori. All patients were giv…