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Computed tomography (CT) colonography is a less-invasive and better-tolerated alternative to colonoscopy as a colorectal cancer (CRC) screening tool in average-risk individuals. However, we know less about its accuracy in detecting advanced colorectal neoplasia in individuals at excess risk for CRC.
Now, researchers have assessed the accuracy of CT colonography in this setting, using unblinded colonoscopy as the reference standard. The European multicenter cross-sectional study involved 937 participants who underwent same-day CT colonography and colonoscopy. All participants had excess risk for CRC, defined by the study as having first-degree relatives with diagnoses of advanced colorectal neoplasia (the family-history group; age range, 40–6…