Chronic Laryngeal Symptoms in Patients with GERD

Acid exposure to the larynx does not appear to be an important cause.

Epidemiological studies consistently show a strong association between laryngeal symptoms and gastroesophageal reflux disease. Studies of proton-pump inhibitor (PPI) therapy have shown favorable results, yet meta-analyses of controlled studies have found no significant differences between placebo and PPI therapy in the resolution of cough and laryngeal disorders.

In a prospective, multicenter, open-cohort European study, researchers assessed the prevalence and course of laryngeal symptoms in adult patients with typical GERD symptoms. The patients were followed for 5 years after treatment with esomeprazole for a maximum of 8 weeks. During the 5-year observational phase of the study, acid antisecretory treatment was left to the discretion of t…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors