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Current therapy for patients with problematic liver cysts is radiographic-guided drainage or surgical resection. However, these techniques are invasive and less feasible for those with multiple cysts. Somatostatin analogues have been shown to reduce cyst volume in polycystic disease in humans and rodent models, likely by activating signaling cascades through inhibitory G protein, which suppresses cyclic adenosine monophosphate.
To assess the efficacy of a long-acting somatostatin analogue in this setting, investigators conducted an industry-supported, multicenter, randomized, double-blind, placebo-controlled trial involving 54 polycystic liver patients who were divided evenly to receive either lanreotide (120 mg) or placebo every 28 days for…