Do Proton-Pump Inhibitors Decrease Bone-Mineral Density?

PPI use was not associated with osteoporosis or accelerated bone-mineral density loss.

Prior epidemiologic results have suggested a possible association between chronic, long-term use of proton-pump inhibitors (PPIs) and excess risk for osteoporosis-related fractures (JW Gastroenterol Oct 3 2008). To further evaluate whether chronic PPI use is linked with osteoporosis, as defined by bone-mineral density (BMD) testing, investigators used the Manitoba Provincial Bone Mineral Density Database to compare approximately 5800 patients who had osteoporosis of the hip or spine (according to dual-energy x-ray absorptiometry [DXA] scanning) and approximately 15,800 controls who did not have osteoporosis. Two separate analyses were performed. All pharmacies in Manitoba are linked directly to this database, and PPIs were not available ove…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors

Do Proton-Pump Inhibitors Decrease Bone-Mineral Density?

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