Is Acid-Reduction Therapy Associated with Risk for Hip Fractures?

Another study adds to the confusion about this potential link.

Multiple retrospective case-control studies have suggested a possible association between proton-pump inhibitor (PPI) use and risk for hip fractures, but these analyses were subject to potential confounding and did not prove causation. A recent study that controlled for many potential confounders showed no link between PPI use and loss of bone-mineral density (JW Gastroenterol Jan 8 2010).

Now, researchers have again investigated the possible association between hip fractures and acid-reduction therapy with PPIs or histamine-2–receptor antagonists (H₂RAs). Using data from a northern California health system, they retrospectively analyzed PPI and H₂RA use among 33,752 people with hip or femur fractures and 130,471 matched controls.

Compared wi…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

Is Acid-Reduction Therapy Associated with Risk for Hip Fractures?

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Reviewing Author