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In a recent cross-sectional study, the presence of large serrated polyps was an independent risk factor for synchronous advanced colorectal neoplasia (JW Gastroenterol May 22 2009). Now, two new studies explore that association further.
The first study involved 3121 patients who underwent screening colonoscopy at 13 Veterans Affairs medical centers. The risk for synchronous advanced neoplasia at the baseline examination was significantly greater for patients who had at least one nondysplastic serrated polyp proximal to the descending colon than for patients who did not (17.3% vs. 10.0%; odds ratio, 1.90). The risk was also significantly greater among patients who had large (≥10 mm) serrated lesions than among those who did not (27.3% vs. 10.…