Succinylated Gelatin for Submucosal Injection of Large Sessile Colon Polyps

Large sessile colon polyps are usually considered the most technically challenging type of polyp to remove. Injecting submucosal fluid to create a cushion between the lesion and the intestinal wall can reduce complications during endoscopic polypectomy. Prior research comparing injectable submucosal fluids showed that a 50% dextrose solution was superior to a standard saline solution but that it was associated with increased risk for postpolypectomy syndrome (JW Gastroenterol Nov 7 2008).

To test another alternative solution, researchers in Australia recently conducted a randomized, double-blind trial that compared outcomes of endoscopic resection using injection of either normal saline (NS) solution or succinylated gelatin (SG) — a safe, co…