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Aspirin use is associated with an increase in complicated gastroduodenal ulcers from both topical and systemic effects. Topical effects include erosions and ulcerations that occur shortly after ingestion of aspirin. To test a novel approach to reducing topical aspirin-induced gastroduodenal damage, investigators conducted an industry-supported, multicenter, randomized, phase II trial of a drug-delivery system that covalently links aspirin to the lipophilic molecule phosphatidylcholine (PC), thus facilitating transit of the resultant aspirin-PC compound across the gastrointestinal (GI) mucosal layer.
A total of 204 healthy individuals (age range, 50–75) with age-related increased risk for nonsteroidal anti-inflammatory drug (NSAID)-induced ga…