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Eradication of Helicobacter pylori infection requires multiple-drug therapy. Given that some of the standard drugs, particularly clarithromycin, lose efficacy because of increasing antibiotic resistance, evaluation of new therapeutic regimens is essential.
To test a new four-drug regimen, European investigators conducted an industry-sponsored, noninferiority, open-label, randomized phase III trial involving 438 patients with H. pylori infection and upper gastrointestinal symptoms. Patients received either quadruple therapy (a single capsule containing bismuth subcitrate potassium, metronidazole and tetracycline, 4 times a day, plus omeprazole twice daily) for 10 days or standard therapy (omeprazole, amoxicillin and clarithromycin twice daily…