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The risk for upper gastrointestinal (UGI) bleeding in patients taking nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) can be reduced by concomitant gastroprotective therapy. However, many patients do not comply with this approach.
To evaluate adherence to gastroprotective therapy and its effect on UGI events, investigators conducted a nested case-control study using three large national databases from the UK, the Netherlands, and Italy. Among a cohort of NSAID users aged ≥50 years who took gastroprotective agents, patients with UGI events were identified. Adherence to gastroprotective therapy was determined using pharmacy data and compared between patients with and without UGI events.
Investigators documented 117,307 episodes of NS…