Linaclotide Effective for Chronic Constipation

Linaclotide is a synthetic peptide that activates the guanylate cyclase C receptor on the surface of intestinal epithelial cells, resulting in secretion of chloride and bicarbonate into the intestinal lumen, thereby accelerating transit. In two similar manufacturer-supported, multicenter, double-blind, phase III trials conducted in the U.S. and Canada, researchers evaluated the safety and efficacy of this agent in adults with chronic constipation.

In all, 1276 patients were randomized to receive linaclotide (145 µg or 290 µg) or placebo, once daily, at least 30 minutes before breakfast. The primary efficacy endpoint was defined as both a weekly frequency of ≥3 complete spontaneous bowel movements (CSBMs) and an increase of ≥1 CSBMs from base…