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Maternal mortality as high as 10% has been reported in pregnant women with cirrhosis. Now, investigators have assessed whether the model for end-stage liver disease (MELD) and similar prognostic scores are able to predict pregnancy outcomes for women with cirrhosis.
The researchers collected data on patients who reported pregnancies at a single medical center in the U.K. between 1984 and 2009. MELD, MELD-Na, and Child-Pugh scores were calculated from information obtained at the clinic visit immediately prior to the report of pregnancy. Outcomes of interest included maternal complications (including hepatic decompensation) and spontaneous abortions.
Sixty-two pregnancies were recorded among 29 women (median age at conception, 29), of whom 24 c…