End-Stage Renal Disease Increases Risk for Gastrointestinal Rebleeding

Multiple studies have shown that the incidence of peptic ulcer disease is decreasing throughout the world. However, upper gastrointestinal bleeding (UGIB) remains a common cause of hospitalization and morbidity. Potential reasons for this situation include unstudied long-term effects of comorbidities.

To assess the long-term effect of end-stage renal disease (ESRD) on the risk for repeat peptic ulcer bleeding, investigators in Taiwan identified 6447 patients with ESRD and 25,788 age- and sex-matched controls without ESRD who were hospitalized for UGIB during a 10-year period. Rebleeding was defined as a repeat hospitalization for UGIB. Data on demographics, drug history, and other possible risk factors for UGIB were also determined from the …