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Gastric cancer is characterized by heterogeneous subtypes with distinct biological properties, and response to treatment is varied and difficult to predict. To determine whether specific genetic subtypes of gastric cancer are associated with response to therapy, investigators tested 37 gastric cancer cell lines and validated findings in primary tumors from 521 patients using immunohistochemical markers LGALS4 and CDH17 to identify gene expression. Also, in vitro sensitivity of the cell lines was assessed for response to 5-fluorouracil (5-FU), cisplatin, and oxaliplatin.
The researchers found that two intrinsic genomic subtypes (G-INT and G-DIF) had distinctive patterns of gene expression and biological pathways and that patients with the G-I…