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Gastric cancer is a major cause of death, and its high incidence in some areas of the world warrants endoscopic screening. Magnifying narrow-band imaging (NBI) has been shown to diagnose mucosal neoplastic lesions more accurately than conventional standard white-light imaging (WLI). Now, investigators in Japan have compared the diagnostic accuracy of the two methods in a multicenter, prospective, randomized trial.
Patients with untreated gastric cancer or with a history of gastric cancer who had been treated with endoscopic mucosal resection were recruited and then screened using WLI. Of these 1351 participants, 362 patients (27%) had newly detected, small (≤10 mm), depressed gastric lesions and were randomized to diagnostic evaluation with …