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Recent studies have shown that patients who develop colorectal cancer after colonoscopy are more likely to have tumors that are located in the proximal colon and that demonstrate microsatellite instability and the CpG island methylator phenotype — features of tumors that develop through the serrated pathway of colorectal cancer. The principal benign precursor of these cancers is believed to be the sessile serrated polyp (or sessile serrated adenoma). To improve detection of these polyps, investigators have now systematically described their endoscopic presentation.
Two endoscopists identified 158 sessile serrated polyps in 124 patients and reviewed video recordings of the lesions. The Paris shape was flat in 98% of the lesions. Endoscopic fe…