PPI Use Associated with Hip-Fracture Risk in Postmenopausal Women

Data from a large, prospective cohort study showed risk to be highest in smokers and in women with lengthy PPI use.

Several studies have suggested an association between proton-pump inhibitor (PPI) use and hip fracture. To explore this issue, investigators used data on PPI use from 79,899 postmenopausal women enrolled in the Nurses' Health Study — a large, prospective cohort study.

During 565,786 person-years of follow-up, 893 hip fractures occurred. The incidence of hip fracture per 1000 person-years was 2.0 in regular PPI users versus 1.5 in nonusers (age-adjusted hazard ratio, 1.35; 95% confidence interval, 1.13–1.62). The risk remained similarly elevated after adjustment for known risk factors and rose with duration of PPI use; it did not vary by indication for PPI prescription. Discontinuation of PPIs for >2 years returned the risk to that of nonuser…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

PPI Use Associated with Hip-Fracture Risk in Postmenopausal Women

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Reviewing Author